5-ALA is a chemical precursor for the creation of the heme molecule which is part of the hemoglobin in the blood
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- Administration of an oral dose of this medicine leads to the production of fluorescent molecules within the glioma cells
- Glioma cells have an increased metabolism and absorb higher doses of this chemical
- A special fluorescent filter attached to the microscope allows the visualization of the glioma tumor which is seen as bright pink when UV light is shone upon it
- Using 5-ALA guidance for the resection of high grade gliomas has been shown to increase extent of resection and improve outcomes.
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